Extraction Of Pipper Betle L. And Formulation Of Herbal Propolis Mouthwash

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Published: May 3, 2025
DOI: https://doi.org/10.24853/jasat.7.3.83-90
Keywords:
Betel leaf Extraction Formulation Herbal propolis mouthwash Inhibitory power.

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Ciska Nabila Wusono
Universitas Muhammadiyah Jakarta
Tri Yuni Hendrawati
Universitas Muhammadiyah jakarta
Ratri Ariatmi Nugrahani
Universitas Muhammadiyah Jakarta
Yustinah Yustinah
Universitas Muhammadiyah Jakarta

Abstract

Betel leaf (Pipper Betle L.) is a climbing plant that has many benefits. Betel leaves have long been used for fever therapy, cough, stomach cramps, anti-allergic, wound healing, antimicrobial, and antiproliferative. Extraction of betel leaves with green solvent requires optimization of the extraction time and percentage of betel leaves with water. Betel and propolis extracts need to be formulated to become an herbal propolis mouthwash. The purpose of this research (1). Getting the best time and percentage of betel leaves in the extraction into betel extract formulated to make herbal propolis mouthwash. (2). Getting the best formula for variations in the percentage of propolis in herbal propolis mouthwash, (3). Conduct a selectivity test to obtain the results of mouthwash as an antibiotic. Based on the results of this research with a comparison of the heating time of betel leaf extraction. Betel leaf extraction was carried out by the infusion method, and the extract was distilled with variations in the percentage of betel leaves of 2.5%, 5%, 7.5%, 10%, 12.5% , and 50% compared with water. The best heating time results for the best betel leaf extraction, based on the yield of betel leaf extraction and pH were 60 minutes. For the optimum betel leaf extraction results at a betel leaf concentration of 50%. Getting a yield value of 40% and pH 4.55 at an extraction time of 60 minutes. The research is still ongoing by conducting a test of the inhibition of Staphylococcus Aureus bacteria in herbal propolis mouthwash with variations in the percentage of propolis of 0%, 2.5%, and 5%.In the blank without the addition of propolis it does not inhibit bacteria Staphylococcus Aureus, the addition of 2.5% and 5% propolis to the herbal propolis mouthwash formula has been proven to inhibit bacteria Staphylococcus Aureus.

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Vol. 7 No. 3 (2025): Journal of Applied Sciences and Advanced Technology
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Articles

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References

Alamsyah, Yenita, Utmi Arma, and Rizq Hidayat. 2021. “Obat Herbal Rebusan Daun Sirih (Piper Betlelinn) Sebagai Obat Kumur Terhadap Kesehatan Rongga Mulut Di Masa Pandemi Covid-19 (Scoping Review).” MENARA Ilmu XV (02): 109–16.

Candrasari, Anika, M. Amin Romas, and Ovi Rizky Astuti. 2011. “UJI DAYA ANTIMIKROBA EKSTRAK ETANOL DAUN SIRIH MERAH (Piper Crocatum Ruiz & Pav.) TERHADAP PERTUMBUHAN Staphylococcus Aureus ATCC 6538, Eschericia Coli ATCC 11229 DAN Candida Albicans ATCC 10231 SECARA IN VITRO.” Biomedika 5 (1): 9–16. https://doi.org/10.23917/biomedika.v4i1.258

Caroline, Caroline, Esa Bella, Tri Erri Astoeti, Abdul Gani Soulisa, Yenny Pragustine, and Deviyanti Pratiwi. 2023. “Pelatihan Pemanfaatan Propolis Dalam Menjaga Kesehatan Gigi Pada Warga Lansia Rt 001/011 Pamulang.” Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) 6 (4): 1344–53. https://doi.org/10.33024/jkpm.v6i4.8877.

Demas, Ghina Beta. 2021. “Pengaruh Lama Perendaman Dalam Larutan Propolis Sebagai Bahan Desinfektan Terhadap Perubahan Warna Basis Gigi Tiruan Termoplastik Nilon GHINA BETA DEMAS, Dr. Drg. Endang Wahyuningtyas, M.S., Sp.Pros(K).; Drg. Heriyanti Amalia Kusuma, S. U., Sp.P” 2 (2020): 30–33.

Dinyanti, Shinta, Roedy Budirahardjo, and Raditya Nugroho. 2020. “Perbedaan PH, Viskositas Dan Volume Saliva Setelah Berkumur Dengan Obat Kumur Sintetik Yang Mengandung Chlorhexidine Dan Larutan Propolis Pada Anak Usia 11-12 Tahun.” Pustaka Kesehatan 7 (3): 158. https://doi.org/10.19184/pk.v7i3.10715.

H.Hanapi, Rizkya Roswati, Alisya Nabila Agustin, Tita Ruhdiana, Selviani Eka Suci, Wanda Indriyani, and Neni Sri Gunarti. 2022. “Potensi Propolis Sebagai Antibakteri : Review Jurnal.” Jurnal Buana Farma 2 (4): 17–24. https://doi.org/10.36805/jbf.v2i4.601.

Haryanti, Sri, Riski Danira Larasati, and Harini Agusta. 2020. “Optimasi Waktu Maserasi Dan Konsentrasi Ekstrak Daun Sirih Hijau (Piper Betle Linn) Dalam Pembuatan Gel Antiseptik Kulit.” Konversi 9 (2): 17–24. https://jurnal.umj.ac.id/index.php/konversi/article/view/8655/5099.

Hasanah, Nur, Fenita Purnama Sari Indah, Dede Anggraeni, Nurwulan Adi Ismaya, and Lela Kania Rahsa Puji. 2020. “Perbandingan Formulasi Dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Lidah Buaya (Aloe Vera) Dengan Perbedaan Konsentrasi.” Edu Masda Journal 4 (2): 132. https://doi.org/10.52118/edumasda.v4i2.104

Milah, Nihayatul, Siti Harnina Bintari, and Dewi Mustikaningtyas. 2016. “Pengaruh Konsentrasi Antibakteri Propolis Terhadap Pertumbuhan Bakteri Streptococcus Pyogenes Secara In Vitro.” Life Science 5 (2): 95–99. http://journal.unnes.ac.id/sju/index.php/UnnesJLifeSci.

Mubarak, Zaki, Santi Chismirina, and Hafizah Humairah Daulay. 2016. “AKTIVITAS ANTIBAKTERI EKSTRAK PROPOLIS ALAMI DARI SARANG LEBAH TERHADAP PERTUMBUHAN Enterococcus Faecalis.” Journal Of Syiah Kuala Dentistry Society 1 (2): 175–86.

Mufrod, Suwaldi, and Subagus Wahyuono. 2016. “Patch Ekstrak Daun Sirih ( Piper Betle L ): Pengaruh Penambahan Release Enhancer Substances Terhadap Sifat Fisikokimia Dan Aktivitas Antibakteri.” Majalah Farmaseutik 12 (2): 431–42.

Noviyanty, Yuska, Farmasi Al-fatah Bengkulu, Analis Kesehatan, and Harapan Bangsa. 2021. “Oceana Biomedicina Journal.” Oceana Biomedicina Journal 4 (1): 38–52.

Pangesti, Rizki Dwi, Edy Cahyono, and Ersanghono Kusumo. 2017. “Indonesian Journal of Chemical Science Perbandingan Daya Antibakteri Ekstrak Dan Minyak Piper Betle L . Terhadap Bakteri Streptococcus Mutans.” Indonesian Journal of Chemical Science 6 (3): 291–99.

Saeed, Muhammad Ali, Abdul Khabeer, Muhammad Ali Faridi, and Ghulam Makhdoom. 2021. “Effectiveness of Propolis in Maintaining Oral Health: A Scoping Review.” Canadian Journal of Dental Hygiene 55 (3): 167–76.

Santos, Vagner Rodrigues, Elizete Maria Rita Pereira, João Luís Duval Cândido Da Silva, Fernando Freitas Silva, Mariana Passos De Luca, Efigênia Ferreira E. Ferreira, and Telma Campos Medeiros Lorentz. 2011. “Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study.” Evidence-Based Complementary and Alternative Medicine 2011. https://doi.org/10.1155/2011/750249.

Suarantika, Farendina, Vinda Maharani Patricia, and Hanifa Rahma. 2023. “Optimasi Proses Ekstraksi Daun Sirih Hijau (Piper Betle L.) Yang Memiliki Aktivitas Antioksidan Berdasarkan Penggunaan Secara Empiris.” Jurnal Ilmiah Medicamento 9 (1): 16–21. https://doi.org/10.36733/medicamento.v9i1.5253.

Sudiana, I Ketut, Walida Pangestuti, and Wahyuni Tri Lestari. 2006. “Propolis Dan Silver Sufadiazin 1 % ( Comparison Of The Effectiveness Between Propolis And Silver Sulfadiazine 1 % On Burn Wound Healing ) I Ketut Sudiana *, Walida Pangestuti *, Wahyuni Tri Lestari *.” Jurnal Ners 4 (2): 128–38.

Sutopo, Tri, Rochmadina Suci Bestari, and Retno Sintowati. 2016. “The Effect of the 70% Ethanol Extract of Betel Leaf (Piper Betle L.) on Bleeding Time in Mice Swiss Webster Strain.” Biomedika 8 (2): 1–8.