Association of Nutritional Status with Quality of Life in Breast Cancer Patients on Chemotherapy

Nanda Noor Muhammad, Aziza Aziza

Abstract


Background: Cancer patients often experience a decline in their nutritional status due to chemotherapy, which can result in malnutrition and negatively impact their quality of life. However, there has been limited research on the prevalence of these conditions in breast cancer patients undergoing chemotherapy in Indonesia. Purposes: This research aims to explore the connection between the quality of life and the nutritional status of breast cancer patients receiving chemotherapy treatment. Methods: A cross-sectional study was conducted in a private hospital in Pekanbaru using non-probability sampling. Demographic profile, nutritional status assessment by PG-SGA, and quality of life assessment by the EORTC QLQ C-30 module were obtained. Mann-Whitney and Spearman's tests analyzed the association between nutritional status and QoL. Results: The average age of breast cancer patients was 45.46±14.375. The prevalence of overweight and obesity was 64.1%. According to the PG-SGA score, the vast majority of patients, approximately 91%, were discovered to be well-nourished. The nutritional status was significantly associated with most functional and symptom scales (p<0.05). Improved nutritional status is associated with increased functionality and a reduction in symptoms, while malnutrition has been linked to decreased quality of life across multiple dimensions. Conclusion: The nutritional status of breast cancer patients affects some dimensions of quality of life. Well-nourished patients had better function and fewer symptoms.

Keywords


breast cancer; chemotherapy; nutritional status; quality of life

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References


Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 May;71(3):209–49.

Kementerian Kesehatan Republik Indonesia. Info Datin Bulan Peduli Kanker Payudara. Kementerian Kesehatan Republik Indonesia; 2016.

Hébuterne X, Lemarié E, Michallet M, de Montreuil CB, Schneider SM, Goldwasser F. Prevalence of malnutrition and current use of nutrition support in patients with cancer. JPEN J Parenter Enteral Nutr. 2014 Feb;38(2):196–204.

Parkinson J, Bandera A, Crichton M, Shannon C, Woodward N, Hodgkinson A, et al. Poor Muscle Status, Dietary Protein Intake, Exercise Levels, Quality of Life and Physical Function in Women with Metastatic Breast Cancer at Chemotherapy Commencement and during Follow-Up. Curr Oncol. 2023 Jan;30(1):688–703.

Badrasawi M, Al-Adhame A, Doufish A. Association of malnutrition and low quality of life among cancer patients receiving chemotherapy, Palestine. East Mediterr Heal J. 2021 May;27(5):459–66.

Vergara N, Montoya JE, Luna HG, Amparo JR, Cristal-Luna G. Quality of life and nutritional status among cancer patients on chemotherapy. Oman Med J. 2013 Jul;28(4):270–4.

Lua PL, Salihah NZ, Mazlan N. Nutritional status and health-related quality of life of breast cancer patients on chemotherapy. Malays J Nutr. 2012 Aug;18(2):173–84.

Afifah VA, Sarwoko. Faktor-faktor yang menpengaruhi kualitas hidup pasien kanker payudara yang menjalani kemoterapi. J Komun Kesehat [Internet]. 2020 Apr 22;11(1 SE-Artikel).

Juwita DAYU, Afdila R. Penilaian Kualitas Hidup Terkait Kesehatan Pasien Kanker Payudara di RSUP Dr. M. Djamil Padang, Indonesia (The Assessment of Health Related Quality of Life for Patients with Breast Cancer in Dr. M. Djamil Hospital Padang, Indonesia). J Ilmu Kefarmasian Indones. 2019;17(1):114–9.

Marwin M, Perwitasari DA, Candradewi SF, Septiantoro BP, Purba FD. Kualitas Hidup Pasien Kanker Payudara Di Rsup Dr. Kariadi Semarang Menggunakan Kuisioner Eortc Qlq-C30. J Ilmu Farm dan Farm Klin. 2021;18(01):16.

Eisenbraun J, Scheer R, Kröz M, Schad F, Huber R. Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract. Phytomedicine. 2011 Jan;18(2–3):151–7.

Hassen AM, Taye G, Gizaw M, Hussien FM. Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. PLoS One. 2019;14(9):e0222629.

Wang H, Zhu L, Lu W, Xu H, Yu Y, Yang Y. Clinicopathological risk factors for recurrence after neoadjuvant chemotherapy and radical hysterectomy in cervical cancer. World J Surg Oncol. 2013;11:1–5.

Prado CM, Purcell SA, Laviano A. Nutrition interventions to treat low muscle mass in cancer. J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):366–80.

Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017 Feb;36(1):11–48.

Foucaut A-M, Morelle M, Kempf-Lépine A-S, Baudinet C, Meyrand R, Guillemaut S, et al. Feasibility of an exercise and nutritional intervention for weight management during adjuvant treatment for localized breast cancer: the PASAPAS randomized controlled trial. Support care cancer Off J Multinatl Assoc Support Care Cancer. 2019 Sep;27(9):3449–61.

Tang F, Wang J, Tang Z, Kang M, Deng Q, Yu J. Quality of Life and Its Association with Physical Activity among Different Types of Cancer Survivors. PLoS One [Internet]. 2016 Nov 3;11(11):e0164971.

Muscaritoli M, Lucia S, Farcomeni A, Lorusso V, Saracino V, Barone C, et al. Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study. Oncotarget. 2017 Oct;8(45):79884–96.

Muscaritoli M, Corsaro E, Molfino A. Awareness of Cancer-Related Malnutrition and Its Management: Analysis of the Results From a Survey Conducted Among Medical Oncologists. Front Oncol. 2021;11:682999.

Jager-Wittenaar H, Ottery FD. Assessing nutritional status in cancer: role of the Patient-Generated Subjective Global Assessment. Curr Opin Clin Nutr Metab Care. 2017 Sep;20(5):322–9.

Brinksma A, Sanderman R, Roodbol PF, Sulkers E, Burgerhof JGM, de Bont ESJM, et al. Malnutrition is associated with worse health-related quality of life in children with cancer. Support care cancer Off J Multinatl Assoc Support Care Cancer. 2015 Oct;23(10):3043–52.

Gellrich N-C, Handschel J, Holtmann H, Krüskemper G. Oral cancer malnutrition impacts weight and quality of life. Nutrients. 2015 Mar;7(4):2145–60.

Kurniawan A, Lugito NPH. Nutritional Status and Quality of Life in Breast Cancer Patients in Karawaci General Hospital. Indones J Cancer. 2016;10(1):1.

Mohammadi S, Sulaiman S, Koon PB, Amani R, Hosseini SM. Association of nutritional status with quality of life in breast cancer survivors. Asian Pac J Cancer Prev. 2013;14(12):7749–55.

Perwitasari DA, Atthobari J, Dwiprahasto I, Hakimi M, Gelderblom H, Putter H, et al. Translation and validation of EORTC QLQ-C30 into Indonesian version for cancer patients in Indonesia. Jpn J Clin Oncol. 2011 Apr;41(4):519–29.

World Health Organization (WHO). Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet (London, England). 2004 Jan;363(9403):157–63.

Elme A, Utriainen M, Kellokumpu-Lehtinen P, Palva T, Luoto R, Nikander R, et al. Obesity and physical inactivity are related to impaired physical health of breast cancer survivors. Anticancer Res. 2013 Apr;33(4):1595–602.

van den Berg MMGA, Winkels RM, de Kruif JTCM, van Laarhoven HWM, Visser M, de Vries JHM, et al. Weight change during chemotherapy in breast cancer patients: a meta-analysis. BMC Cancer. 2017 Apr;17(1):259.

Makari-Judson G, Braun B, Jerry DJ, Mertens WC. Weight gain following breast cancer diagnosis: Implication and proposed mechanisms. World J Clin Oncol. 2014 Aug;5(3):272–82.

de Kruif AJt, Westerman MJ, Winkels RM, Koster MS, van der Staaij IM, van den Berg MMGA, et al. Exploring changes in dietary intake, physical activity and body weight during chemotherapy in women with breast cancer: A Mixed-Methods Study. J Hum Nutr Diet Off J Br Diet Assoc. 2021 Jun;34(3):550–61.




DOI: https://doi.org/10.24853/mmj.5.1.9-19

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