Preliminary Study of Cinnamomum burmannii Extracts to Reduce Fasting Blood Glucose Level and Body Weight in Type-2-DM-Induced Rats
Abstract
Background: Diabetes mellitus prevalence in Indonesia tends to be elevated based on glucose measurement. Antidiabetic oral has some serious side effects for long-term use. Several studies explored various types of Cinnamomum extract's effects on antidiabetic activity and potentially became an alternative therapy in Diabetes mellitus patients. Purposes: This study aimed to determine Cinnamomum burmannii extract’s effect on body weight and fasting blood glucose level in rats induced Type-2 DM. Methods: This study was conducted at the Laboratory of the Faculty of Pharmacy and Science, University Muhammadiyah of Prof. DR. Hamka. This study design was a true experimental method by administering Cinnamon extract at 30mg/kg, 60mg/kg, 120mg/kg, and 200mg/kg to animal tests. The statistical analysis used a T-test to compare the different results in parameters before and after the administration of Cinnamon extract. Results: This study shows a difference in blood sugar level and body weight before and after the cinnamon extract group administration. The body weight results presented no significant differences between before and after administering Cinnamon extracts at doses of 30mg/kg, 60mg/kg, 120mg/kg, and 200mg/kg. In contrast, the blood sugar level showed significant differences between before and after administration of Cinnamon extract at group doses (p<0.05). Metformin was still more influential in reducing fasting blood sugar than Cinnamomum burmannii extract at 30mg/kg. Conclusion: This study concluded that Cinnamomum burmannii extract with various doses could reduce fasting blood glucose levels and body weight. The highest dose showed a significant difference in fasting blood glucose levels before and after the administration of extracts.
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Kementerian Kesehatan RI. Infodatin tetap produktif, cegah, dan atasi Diabetes Melitus 2020. Pusat Data dan Informasi Kementerian Kesehatan RI. 2020. p. 1–10.
Samalagi GO, Mongie J, Tampa’i R, Kanter JW. Uji Efektivitas Antidiabetes Ekstrak Bunga Centrosema Centrosema Pusbescens B. Pada Tikus Putih Rattus norvegicus Yang Diinduksi Aloksan. Trop J Biopharm. 2019;2(2):158–69.
Emilda E. Efek Senyawa Bioaktif Kayu Manis Cinnamomum burmanii Nees Ex.Bl.) Terhadap Diabetes Melitus: Kajian Pustaka. J Fitofarmaka Indones. 2018;5(1):246–52.
Goel B, Mishra S. Medicinal and Nutritional Perspective of Cinnamon : European J Med Plants. 2020;31(3):10–6.
Ahmed HM, Ramadhani AM, Erwa IY, Ishag OAO, Saeed MB. Phytochemical Screening, Chemical Composition and Antimicrobial Activity of Cinnamon verum Bark. Int Res J Pure Appl Chem. 2020;21(11):36–43.
Rahayu DUC, Hakim RA, Mawarni SA, Satriani AR. Indonesian Cinnamon (Cinnamomum burmannii): Extraction, Flavonoid Content, Antioxidant Activity, and Stability in the Presence of Ascorbic Acid. Cosmetics. 2022;9(57):1–15.
Kawi JS, Yulianti E, Limanan D, Ferdinal F. Phytochemicals Profiling and Total Antioxidant Capacity of Cinnamon Bark Extract ( Cinnamomum burmanii ). Adv Heal Sci Res. 2021;41:33–8.
Santos HO, da Silva GAR. To what extent does cinnamon administration improve the glycemic and lipid profiles? Clin Nutr ESPEN [Internet]. 2018;27:1–9. Available from: https://doi.org/10.1016/j.clnesp.2018.07.011
Deyno S, Eneyew K, Seyfe S, Tuyiringire N, Peter EL, Muluye RA, et al. Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression. Diabetes Res Clin Pract [Internet]. 2019;156:1–14. Available from: https://doi.org/10.1016/j.diabres.2019.107815
Medagama AB. The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials. Nutr J. 2015;14(1):108.
Padugupati S, Ramamoorthy S, Thangavelu K, Sarma D, Jamadar D. Effective Dose of Streptozotocin to Induce Diabetes Mellitus and Variation of Biophysical and Biochemical Parameters in Albino Wistar Rats. 2021;1–5.
Damasceno DC, Netto AO, Iessi IL, Gallego FQ, Corvino SB, Dallaqua B, et al. Streptozotocin-Induced Diabetes Models : Pathophysiological Mechanisms and Fetal Outcomes. Biomed Res Int. 2014;1–11.
Nurinda E, Kusumawardani N, Wulandari AS, Fatmawati A, Emelda E, Nisa H. Pharmacological Study : Synergistic Antidiabetic Activity of Cinnamon Bark and Zingiber Extract in Streptozotocin-Induced Diabetic Rats. 2022;10:1–6.
Qureshi AS, Ghaffor J, Usman M, Ehsan N, Umar Z, Sarfraz A. Effect of ethanolic preparations of cinnamon ( Cinnamomum zeylanicum ) extract on hematologic and histometric parameters of selected organs in Alloxan ® induced diabetic female albino rats. 2019;505–12.
Shari J, Dey A, Koirala N, Shaheen S. Cinnamomum Species : Bridging Phytochemistry Knowledge , Pharmacological Properties and Toxicological Safety for Health Bene fi ts. Front Pharmacol. 2021;12:1–27.
Błaszczyk N, Rosiak A. The Potential Role of Cinnamon in Human Health. Forests. 2021;12(648):1–17.
Syafriani, Verawati B. Pengaruh Ekstrak Kayu Manis Terhadap Penurunan Kadar Gula Darah Pada Penderita DM Tipe II di Desa Kumantan Wilayah Kerja Puskesmas Bangkinang Kota. J Ners Univ Pahlawan Tuanku Tambusai. 2017;1(2):90–5.
Zhu R, Liu H, Liu C, Wang L, Ma R, Chen B, et al. Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety. Pharmacol Res. 2017 Aug;122:78–89.
Saputra NT, Suartha IN, Dharmayudha AAGO. Agen Diabetagonik Streptozotocin untuk Membuat Tikus Putih Jantan Diabetes Mellitus. Bul Vet Udayana. 2018;10(2):116–21.
Ouahhoud S, Khoulati A, Kadda S, Bencheikh N, Mamri S, Ziani A, et al. Antioxidant Activity , Metal Chelating Ability and DNA Protective Effect of the Hydroethanolic Extracts of Crocus sativus Stigmas , Tepals and Leaves. Antioxidants. 2022;11(932):1–21.
Maulana F, Safithri M, P UMS. Aktivitas Antioksidan dan Antidiabetes In Vitro Ekstrak Air Kulit Batang Kayu Manis ( Cinnamomum burmannii ) Asal Kota Jambi In Vitro Antioxidant and Antidiabetic Activities of Aqueous Extract of Cinnamon Bark ( Cinnamomum burmannii ) from Jambi. J Sumberd Hayati. 2022;8(2):42–8.
Alsoodeeri FN, Alqabbani HM, Aldossari NM. Effects of Cinnamon ( Cinnamomum cassia ) Consumption on Serum Lipid Profiles in Albino Rats. J Lipids. 2020;2020.
Faddladdeen KA jalil. Saudi Journal of Biological Sciences The possible protective and therapeutic effects of ginger and cinnamon on the testis and coda epididymis of streptozotocin-induced-diabetic rats : Histological and biochemical studies. Saudi J Biol Sci [Internet]. 2022;29(12):1–7. Available from: https://doi.org/10.1016/j.sjbs. 2022.103452
Kaul K, Apostolopoulou M, Roden M. Insulin resistance in type 1 diabetes mellitus. Metabolism. 2015;64(12).
Han X, Tao Y-L, Deng Y-P, Yu J-W, Cai J, Ren G-F, et al. Metformin ameliorates insulitis in STZ-induced diabetic mice. PeerJ. 2017;5:1–13.
Siswandi I, Sofiani Y, Irawati D. Effectiveness of steeping cinnamon (Cinnamon Burmanni) and red ginger (Zingiber Officinale) on blood glucose levels in patients with type 2 diabetes mellitus. J Heal Stud. 2019;4(1):54–65.
Safithri M, Bintang M, Syaefudin. Blood Glucose Level , Langerhans Pancreas and Lipid Profile of Diabetic Rats After Administration of Red Betel , Ginger and Cinnamon Combination Extract. Trop Life Sci Res. 2023;34(1).
DOI: https://doi.org/10.24853/mmj.5.2.107-115
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