3.jpg)
Hypertension in elderly: A study of hypertension in epigenetic perspective
Abstract
Background: as is known, epigenetic events are defined as modifications in phenotype or gene expression, which caused by interactions between genes and the environment without changing the order of their nitrogenous bases. This article will discuss the role of epigenetics in one of the degenerative diseases that are often found in the elderly, namely hypertension. In this review article, we will mainly discuss the events of histone modification and DNA methylation, for example, DNA methylation in the CpG islands and the acetylation of histone pathway are identified to limit the development of nephrons, thus opening up to lhypertension-related with exposure to high salt diets. Results: lack of maternal water and protein deficiency have been shown to increase the appearance of the renin-angiotensin system gene in the children. Conclusion: these results indicate targets for the interaction of environmental genes in various conditions of hypertension and essential hypertension.
Keywords
Full Text:
PDFReferences
Kotchen TA, Liu Y. Epigenomics of Hypertension. Semin Nephrol. Elsevier; 2013;33(4):392–9.
Liang M. Epigenetic mechanisms and hypertension. Hypertension. 2018;72(6):1244–54.
Koleganova N, Piecha G, Ritz E. Prenatal Causes of Kidney Disease. Blood Purif. 2009;27:48–52.
Rose NR, Klose RJ. Biochimica et Biophysica Acta Understanding the relationship between DNA methylation and histone lysine methylation. Biochim Biophys Acta. Elsevier B.V.; 2014;1839(12):1362–72.
Deaton AM, Bird A. CpG islands and the regulation of transcription CpG islands and the regulation of transcription. Genes Dev. 2011;25:1010–22.
Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA ( cytosine-5 ) methyltransferases Non-invasive sexing of preimplantation stage mammalian embryos. Nat Genet. 1998;19:219–20.
Oh JH, Gertych A, Tajbakhsh J. Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating / Aging , Rapidly Growing / Immortal , and Senescent Cells. Oncotarget. 2013;4(3):474–93.
Wise IA, Charchar FJ. Epigenetic Modifications in Essential Hypertension. Int J Mol Sci. 2016;17(451):1–14.
Shim CY, Ha J, Park S, Choi E, Korea S. Exaggerated Blood Pressure Response to Exercise Is Associated With Augmented Rise of Angiotensin II During Exercise. J Am Coll Cardiol. 2008;52(4):287–92.
Pei F, Wang X, Yue R. Differential expression and DNA methylation of angiotensin type 1A receptors in vascular tissues during genetic hypertension development. Mol Cell Biochem. 2015;
Bogdarina I, Welham S, King PJ, Burns SP, Clark AJL. Epigenetic Modification of the Renin-Angiotensin System in the Fetal Programming of Hypertension. Circ Res. 2007;100:520–6.
Goyal R, Goyal D, Leitzke A, Gheorghe CP, Longo LD. Brain Renin-Angiotensin System : Fetal Epigenetic Programming. Reprod Sci. 2010;17(3):227–38.
Yu Z, Kong Q, Kone BC. CREB trans -activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells. Am Physiol Soc. 2020;298(9):617–24.
Stein AB, Jalife J, Dressler GR, Stein AB, Jones TA, Herron TJ, et al. Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest. 2011;121(7):2641–50.
Peserico A, Simone C. Physical and Functional HAT / HDAC Interplay Regulates Protein Acetylation Balance. J Biomed Biotechnol. 2011;2011:1–10.
Berger SL. Histone modifications in transcriptional regulation. Curr Opin Genet Dev. 2002;12:142–8.
Shiio Y, Eisenman RN. Histone sumoylation is associated with transcriptional repression. PNAS. 2003;100(23):13225–30.
Lee H, Cho H, Lee D, Kim K, Han HS, Kim IK. Enzyme 1 in Spontaneously Hypertensive Rats Through Histone Code Modifications. Hypertension. 2012;59:621–6.
DOI: https://doi.org/10.24853/mujg.1.1.23-28
Refbacks
- There are currently no refbacks.
Indexed by:
15.jpg)
Ciptaan disebarluaskan di bawah Lisensi Creative Commons Atribusi-NonKomersial 4.0 Internasional.
Copyright of Muhammadiyah Journal of Geriatric (e issn: 2721-6837)