Effectiveness of Quercetin in Kenikir Leaves (Cosmos Caudatus Kunt) in Nanoemulsion Formulas with VCO (Virgin Coconut Oil) and Olive Oil Phase
DOI:
https://doi.org/10.24853/jurtek.16.2.195-202Keywords:
Antioxidant, Kenikir (Cosmos Caudatus Kunth), Nanoemulsion, Olive Oil, Quercetin, VCO (Virgin Coconut Oil)Abstract
Kenikir (Cosmos Caudatus Kunth) is a herbal plant and contain quercetin compounds (flavonoids) which can have an effect as an antioxidant, antibacterial, antifungal, anti-inflammatory. This study aims to determine the effect of adding quercetin extract to a nanoemulsion formula with several oil phases, namely VCO (Virgin Coconut Oil) and Olive Oil. Evaluation of the characteristics of the preparation for each formula included organoleptic test, pH test, particle size, emulsion type, and determination of the level of quercetin absorbed in the nanoemulsion system as well as antioxidant activity test using the DPPH (1,1-diphenyl-2-picrylhydrazil) method. The results showed that the nanoemulsion preparations with the VCO oil phase, olives had good and stable characteristics. The pH test of the nanoemulsion was in the range of 4.5-6.5 while for the emulsion type it was an Oil in Water (M/A) type and the particle size was in accordance with the criteria for nanoemulsion preparations <200 nm, namely 13-178 nm. To see the ability of the active substance to be absorbed in the formula by calculating the % EE (Entrapping Efficiency) the % EE is obtained, which is 99%, which means that the nanoemulsion formula is able to absorb the active substance well and the antioxidant activity test using the DPPH method shows in the formulation of kenikir extract with the VCO oil phase gives an IC50 value of 52.238 ppm while the olive oil phase is 305.783 so that the nanoemulsion formula with the VCO oil phase is more reactive than the olive oil phase.Downloads
References
Anggresani, Lia. 2017. Test for Total Flavanoid Content and Antioxidant Activity of Kembang Bulan Leaf Extract (Thitonia deiversifolia (Hemsley) A. Gray). Pharmacy Study Program. STIKES Mother's Hope. Jambi
Chen, et al, H. 2011. Nanonization strategies for poorly water-soluble drugs. Drug Discovery. Today 16: 354–360.
Ministry of Health of the Republic of Indonesia. 2008. Indonesian Herbal Pharmacopeia, Jakarta: Ministry of Health of the Republic of Indonesia
Devarajan, V. and Ravichandhandran, V. 2011. Nanoemulsions: as Modified Drug Delivery Tool. Pharmacie Globale, 2(4), 1-6
Dwi, Anita. Prayogo, Lean, S. 2016. Comparison of Maceration and Soxhletation Extraction Methods on Total Phenolic Content of Kersen Leaf Ethanol Extract (Muntingia Calabura). Inside: Bachelor of Pharmacy Research. Wahid Hasyim University. Semarang
Lawrence, MJ, 2000. Microemulsion-based media as a novel drug delivery system. Adv. Drug Delivery Rev. 45(1):89-121
Lotulung, PDN, Minarti, and Kardono, LBS, 2005, Screening for antibacterial activity, antioxidants and toxicity to shrimp larvae Artemia salina Asteraceae plant extract, Abstract, LIPI Chemical Research Center.
Malvern. 2012. A Basic Guide to Particle Characterization. Worcestershire (UK): Malvern Instruments Limited
Martin, A., Swarbrick, J., Commarata, A. 1993. Physical Pharmacy 3rd Edition (Translation by Yoshita and Iis Aisyah B). Jakarta: University of Indonesia Press
Pham, Thi Thuy. 2012. Colloid and Surfaces B: Biointerfaces, Liposome and Niosome Preparation Using Membrane Contractor for Scale Up . France, 94, 15-21
Reynertson, KA 2007. Phytochemical analysis of bioactive constituents from edible myrtaceae fruit. University of New York, New York.
School. 1988. Purity Supplementary Material for Drug Separation Method. Gadjah Mada University. Yogyakarta: University Press
Talapessy, S., Suryanto, E., & Yudistira, A. (2013). Antioxidant activity test of sago waste (Metroxylon sago Rottb). Pharmaceutical Scientific Journal, 2(3), 40-44.
Utami, Holy Syafitri. 2012. Formulation and InVitro Penetration Test of Nanoemulsion, Nanoemulsion Gel, and Curcumin Gel [thesis]. Depok: Faculty of Mathematics and Natural Sciences, Pharmacy Study Program
Zahratunnahdhatili'ibaadatillaah. 2017. Effect of Kenikir (Cosmos Caudatus Kunt) Leaf Extract Concentration on the Characteristics and Release of Active Compounds in the Nanoemulsion System using the Virgin Coconut Oil (VCO) Oil Phase. Inside: Proceedings of Civitas Research at the State Islamic University of Maulana Malik Ibrahim.Malang
Winarno. 2008. Food and Nutrition. Jakarta: Gramedia
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